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Simultaneous Myelin Water, Magnetic Susceptibility, and Morphometry Analyses Using Magnetization-prepared Multiple Spoiled Gradient Echo

Hirohito Kan^1,2, Yuto Uchida³, Yoshino Ueki⁴, Satoshi Tsubokura⁵, Hiroshi Kunitomo⁵, Harumasa Kasai⁵, Noriyuki Matsukawa³, and Yuta Shibamoto²
¹Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan, ²Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, ³Department of Neurology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, ⁴Department of Rehabilitation Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, ⁵Department of Radiology, Nagoya City University Hospital, Nagoya, Japan

1. MP-mSPGR sequence is feasible for simultaneous voxel-based MWF, magnetic susceptibility, and morphometry on a single scan.

2. By using MP-mSPGR sequence, it is possible to accurately estimate the effect of iron deposition against MWF.

Figure 2 Representative images of (a, e) magnitude image of the first echo in magnetization-prepared multiple spoiled gradient echo sequence, (b, f) white matter image, (c, g) myelin water fraction map, and (d, h) susceptibility map in patients with Alzheimer’s disease and healthy control groups.

Figure 1 Schematic flowchart of preprocessing for simultaneous voxel-based myelin water, magnetic susceptibility, and morphometry analysis. The magnitude image of the first echo in MP-mSPGR, which has strong T1 contrast, is segmented and normalized for voxel-based morphometry (VBM). Myelin water fraction map is estimated from the magnitude image corrected macroscopic field inhomogeneity. The susceptibility map is estimated from multiple phase images. The MWF and susceptibility maps were spatially normalized using the same transformation parameter for VBM.