Logan Xin Zhang1 and Michael A Chappell1,2,3
1Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, 2Radiological Sciences, Division of Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 3Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom
1Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, 2Radiological Sciences, Division of Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 3Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom
An extended kinetic model explicitly accounting for macrovascular signal is beneficial to CBF estimation in pCASL protocols, reducing CBF sensitivity to macrovascular contamination to up to 2.3 seconds of tissue ATT.
Figure 2. CBF sensitivity maps to macrovascular contamination by eight protocols (a to h) and average (i). Each protocol has CBF maps estimated by GKM (left), GKMmvc (middle), and their difference (GKMmvc - GKM, right). Units: error% per 1% aBV.
Figure 3. CBF sensitivity as a function of tissue ATT across protocols under three assumptions. (a) Percentage; (b) Fixed; (c) Fixed interval. Each assumption has CBF maps estimated by GKM (left), GKMmvc (middle), and their difference (GKMmvc - GKM, right). Units: error% per 1% aBV.