Petros Martirosian1, Rolf Pohmann2, Martin Schwartz1,3, Thomas Kuestner4, Manuel Kolb4, Ahmed Othman4, Cecilia Zhang4, Klaus Scheffler2,5, Konstantin Nikolaou4, Fritz Schick1, and Ferdinand Seith4
1Section on Experimental Radiology, University of Tübingen, Tübingen, Germany, 2Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 3Institute of Signal Processing and System Theory, University of Stuttgart, Stuttgart, Germany, 4Department of Diagnostic and Interventional Radiology, University of Tübingen, Tübingen, Germany, 5Department of Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany
1Section on Experimental Radiology, University of Tübingen, Tübingen, Germany, 2Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 3Institute of Signal Processing and System Theory, University of Stuttgart, Stuttgart, Germany, 4Department of Diagnostic and Interventional Radiology, University of Tübingen, Tübingen, Germany, 5Department of Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany
Pseudo-continuous
arterial spin labeling (PCASL) is able to detect changes of
parenchymal lung perfusion caused by alterations of the intrathoracic
pressure. Perfusion signal measured under end-inspiratory condition was noticeably
reduced as
compared to end-expiratory breath-hold.
Figure
2: PCASL perfusion-weighted
images of three healthy volunteers acquired under expiratory, inspiratory and
free-breathing conditions. One pair and twelve pairs of label-control images
were measured in breath-hold and free-breathing examinations,
respectively.
Figure
1: Spatial arrangement of
labeling and imaging planes on a sagittal image in PCASL measurements. The
labeling plane (red) was positioned nearly perpendicular to the pulmonary trunk
(yellow arrow) and images were acquired in coronal orientation (green). Time
course of ECG-triggered PCASL sequence: labeling duration (τ) was
limited to the systolic period and imaging was performed in diastole of successive
cardiac cycle by adapting post-labeling delay (PLD).
