Olayinka Adeoluwa Oladosu1, Cayden Murray2, Syed Rizvi2, Mariana Bento3,4, G Bruce Pike3,4, and Yunyan Zhang3,4
1Neuroscience, University of Calgary, Calgary, AB, Canada, 2University of Calgary, Calgary, AB, Canada, 3Radiology, University of Calgary, Calgary, AB, Canada, 4Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
1Neuroscience, University of Calgary, Calgary, AB, Canada, 2University of Calgary, Calgary, AB, Canada, 3Radiology, University of Calgary, Calgary, AB, Canada, 4Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
Women and men appear
to have different microstructure patterns in multiple sclerosis. Men had greater
lesion microstructural damage and women showed different microstructure
patterns associated with injectable and oral medications according to diffusion
MRI.
Figure 1.
Lesion-NAWM asymmetries compared between men and women. Diffusion tensor
imaging (top), high angular resolution compartment (middle), and diffusion orientation
analyses indicate differences in lesion-NAWM asymmetry between women and men. *p<0.05,
**p<0.01
Figure 2. Diffusion
metrics reflecting significant differences in microstructure pathology between
men and women. Calculation of diffusion measures took advantage of the A) average
diffusion b0. Measures showing significant sex-differences in microstructure
include B) radial diffusivity, C) mean diffusivity, and D) fractional
anisotropy diffusion tensor measures as well as E) axonal density, F) axonal
diameter, G) intracellular volume fraction and H) orientation distribution
function energy.
