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Greater increase in magnetic susceptibility following acute MS lesion formation is associated with reduced myelin repair
Lily Zexter1, Thanh D. Nguyen2, Elizabeth M. Sweeney3, Yi Wang2, and Susan A. Gauthier1
1Department of Neurology, Weill Cornell Medicine, New York, NY, United States, 2Department of Radiology, Weill Cornell Medicine, New York, NY, United States, 3Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, United States
We analyzed 49 new Gadolinium-enhancing MS lesions and found that that the change in lesion QSM at three months was significantly and negatively associated with change in myelin water fraction at one year.
Figure 4: Mixed model results
Figure 1: Example of MS lesion with greater initial change in susceptibility and less myelin recovery at 12 months