Kyle Jeong1, Lubdha Shah2, You-Jung Lee1, Bijaya Thapa1, Nabraj Sapkota1, Erica Bisson3, Noel Carlson4, Eun-Kee Jeong2, and John Rose5
1Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, UT, United States, 2Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States, 3Neurosurgery, University of Utah, Salt Lake City, UT, United States, 4GRECC, Veterans Affairs, Salt Lake City, UT, United States, 5Neuroimmunology and Neurovirology Division, University of Utah, Salt Lake City, UT, United States
1Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, UT, United States, 2Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States, 3Neurosurgery, University of Utah, Salt Lake City, UT, United States, 4GRECC, Veterans Affairs, Salt Lake City, UT, United States, 5Neuroimmunology and Neurovirology Division, University of Utah, Salt Lake City, UT, United States
The main objective of this study was to present UHb-rDWI as a potential powerful tool in quantitatively characterizing MS CSC. We investigate UHb-rDWI signal in white matter tracts of the CSC and compare quantitative values between healthy control WM with both MS NAWM and WM lesions.
Fig. 1. MS1: (a) DWIs of b = 1700 ~ 7350 s/mm2 of the lesion slice and (b) ROIs at lesion and NAWM slice, 1.5 cm above the lesion toward the brain, and (c) signal-b curves of the recently-active lesion (red square) and NAWM (red circle), and averaged data (hollow square) at the corticospinal tract of seven healthy subjects, and (d) mean values of high-b diffusion coefficient DH at the lesion, NAWM, and the healthy CSCs at the corticospinal tract. Green dotted line in (b) indicates the MCS data with 30 % demyelination in lesion.
Fig. 2. MS2: (a) T2WI, (b, c) DWIs of b = 1700 ~ 7350 s/mm2 of the lesion slice and NAWM slice, 1.5 cm below the lesion away from the brain, (d) ROIs on lesion (top) and NAWM (bottom), (e) signal-b curves of the recently-active lesion, NAWM, and averaged data at the posterior column of 7 HS, and (f) mean values of high-b diffusion coefficient DH at the lesion, NAWM, and the healthy CSCs at the corticospinal tract. White vertical arrows in (a) indicate lesion with rapidly decaying signal. Green dotted lines in (e) indicate the MCS data with 40 % and 15 % demyelination in lesion and NAWM, respectively.
