Liangdong Zhou1, Yi Li1, Xiuyuan Hugh Wang1, Elizabeth Sweeney1, Hang Zhang1,2, Emily B Tanzi1, Jennette Prince2, Victor Antonio Su-Ortiz2, Susan A Gauthier1, and Thanh D Nguyen1
1Radiology, Weill Cornell Medicine, New York, NY, United States, 2Cornell University, Ithaca, NY, United States
1Radiology, Weill Cornell Medicine, New York, NY, United States, 2Cornell University, Ithaca, NY, United States
Multi-echo T2 relaxometry-based water compartment model can be used to quantify CSF water fraction (CSFF). It turns out that the CSFF increases with age in the cortical gray matter from a cohort of non-active MS subjects. CSFF could be a potential biomarker of perivascular space.
Figure 3 CSFF with age in four cortical lobes. It clearly shows that the CSFF increases with age in all cortical lobes (Frontal: p=0.019, occipital: p<0.01, Parietal: p<0.01, temporal: p<0.01, all p-values are FDR adjusted).
Figure 2. WM CSFF and PVS score relation. PVS score was evaluated on the T2w image at the semiovale slice and the WM CSFF was measured at the WM region of the same slice. It shows CSFF increases as the PVS score increases.
