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Reproducibility of Semi-LASER Localized Correlated Spectroscopic Imaging Using Concentric Ring Echo-Planar Trajectories

Andres Saucedo¹, Manoj Kumar Sarma¹, Uzay Emir², James Sayre¹, Paul M Macey³, and Michael Albert Thomas¹
¹Radiological Sciences, UCLA Geffen School of Medicine, Los Angeles, CA, United States, ²School of Health Sciences, Purdue University, West Lafayette, IN, United States, ³UCLA School of Nursing, Los Angeles, CA, United States

Test-retest reproducibility of a novel 5D COSI-CONCEPT sequence was validated using a GE Braino on two different 3T MRI scanners. The phantom was scanned on different days and we observed excellent coefficients of variance (CV) and intra-class correlation coefficients for all 6 metabolites

Fig. 2: (Top) Three-plane localization of the volume-of-interest (VOI) in the brain phantom. The VOI size was 10.5cm × 10.5cm × 7.5cm and the field-of-view (FOV) for spectroscopic imaging was 24cm × 24cm × 12cm along the left-to-right (L-R), anterior-to-posterior (A-P) and foot-to-head (F-H) directions, respectively. Sixteen voxels (red square) within the VOI were quantified. (Bottom) Axial NAA maps acquired along the F-H dimension within the FOV. Signal from five slices was measurable within the VOI, which had an extent of 7.5 cm along F-H.

Fig. 3: Multi-voxel contour plots of COSY spectra from the central slice of the brain phantom. Sixteen voxels within a 4 x 4 region (red square) inside the volume-of-interest (VOI) were quantified using peak integration to compute metabolite ratios for the reproducibility analysis.