Tianzhe Li1, Aikaterini Kotrotsou1, Shu Zhang1, Kyle Jones1, and Mark Pagel1
1Cancer Systems Imaging, UT MD Anderson Cancer Center, Houston, TX, United States
1Cancer Systems Imaging, UT MD Anderson Cancer Center, Houston, TX, United States
Our Bloch-fitting algorithm can quantify the changes of kex
of iopamidol amide protons with sample pH levels and temperatures. We have
confirmed that including experimentally measured information can increase the
accuracy of the fitting results.
Figure 3. Bloch fitted kex with different
fitting conditions for the 5.6 ppm amide proton in 25 mM iopamidol solutions
with different T1 values. The analyzed spectra were acquired at 37
°C with a saturation power of 3.0 μT and a saturation time of 6.0 sec.
Figure 4. The computation time for the Bloch-fitting
process with different fitting conditions. For each fitting condition, the
computation time presented includes data for the fitting of the spectra of
twenty-four 25 mM iopamidol samples scanned at five temperatures (i.e. 120
spectra per fitting condition).
