Jan N Rose1, Ignasi Alemany1, Andrew D Scott2,3, and Denis J Doorly1
1Department of Aeronautics, Imperial College London, London, United Kingdom, 2Cardiovascular Magnetic Resonance unit, Royal Brompton Hospital, London, United Kingdom, 3National Heart and Lung Institute, Imperial College London, London, United Kingdom
1Department of Aeronautics, Imperial College London, London, United Kingdom, 2Cardiovascular Magnetic Resonance unit, Royal Brompton Hospital, London, United Kingdom, 3National Heart and Lung Institute, Imperial College London, London, United Kingdom
We extend our existing, histology-based Monte Carlo random walk simulations of DT-CMR with a model for permeable cell membranes. Results show that values of FA move closer towards in-vivo expectations when considering permeability.
2D illustration of the virtual histology-based geometry used in the simulations. Myocytes are triangular meshes (polyhedra). The extra-cellular volume fraction is 22%.
FA and MD values for two extreme permeability cases ($$$\kappa$$$=0 and 0.05μm/ms). All simulations have been computed considering a STEAM sequence with increasing $$$\Delta$$$ and constant gradient strength and duration. Parameters: $$$N_p$$$=104 walkers, $$$D_\text{ICS}$$$=1.5µm2/ms and $$$D_\text{ECS}$$$=3µm2/ms.