Atena Akbari1, Saskia Bollmann1, and Markus Barth1,2,3
1Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, 2School of Information Technology and Electrical Engineering, Brisbane, Australia, 3ARC Training Centre for Innovation in Biomedical Imaging Technology, Brisbane, Australia
1Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, 2School of Information Technology and Electrical Engineering, Brisbane, Australia, 3ARC Training Centre for Innovation in Biomedical Imaging Technology, Brisbane, Australia
Using a cortical vascular model, we simulated the depth-dependent BOLD and VASO signal change in human primary motor cortex.
Figure 2. The first row shows
the pattern of the CBV change across the layers used in our simulation. Rows 2 to 5 show the BOLD and VASO simulated
profiles. Profiles with RMSE 20% higher than the minimum RMSE are plotted as
the shaded area. In all figures the horizontal axes show the relative cortical
depth, vertical axes show the percentage of signal change, solid lines
represent imaging data, dotted lines represent simulated responses, and error
bars show the standard error of the mean.
Figure 1. A) Schematic
representation of the modelled primary motor cortex centred on two adjacent
principal veins of groups 3 and 4 (V3, V4) with artery to vein ratio of 2-1. B)
Baseline blood volume in intracortical vessels and the laminar network (i.e.
arterioles, capillaries, and venules) in the modelled area.