Henriette Lambers1, Lydia Wachsmuth1, Ping Zheng1, and Cornelius Faber1
1Translational Research Imaging Center, Clinic for Radiology, University Hospital Muenster, Muenster, Germany
1Translational Research Imaging Center, Clinic for Radiology, University Hospital Muenster, Muenster, Germany
We developed a detection tool for
periodic BOLD oscillations in fMRI data with a detection specificity of 96 %
. Analysis of high temporal resolution rat fMRI data showed that
BOLD oscillations occur brain wide during long-term anaesthesia, which should
be considered for brain network analyses.
fig. 5: Color coding for number of measurements that showed
oscillations for resting state. Regions in which at least 20 % of the data
showed oscillation are shown for the right hemisphere at bregma 1.0. For group
1 and 2 (A and B), data was separated into early (first 3 hours) and late. Only
late datasets showed oscillations in all regions. In group 3 and 4 (C and D), oscillation
occurred not under isuflurane, but under medetmidine in cortical regions.
Stimulation data showed similar results.
fig. 1: Exemplary time courses without and with BOLD
oscillations for both, (A) resting state and (B) electrical paw stimulation.
Stimulation phases are indicated by a grey bar.
