Shabnam Khorasani Gerdekoohi1, Pankaj Sah2, and Kai-Hsiang Chuang1,3
1Queensland Brain Institute, Brisbane, Australia, 2Quuensland Brain Institute, Brisbane, Australia, 3Center for Advanced Imaging, Brisbane, Australia
1Queensland Brain Institute, Brisbane, Australia, 2Quuensland Brain Institute, Brisbane, Australia, 3Center for Advanced Imaging, Brisbane, Australia
This study established a method to measure high quality BOLD and calcium
activation in mouse with multiple implants. This enables studying functional
connectivity in the future.
Fig.1. GE-EPI of the
mouse brain. Susceptibility artefacts under different combinations of fiber
diameters (200/100/60 µm) and dental cements (Meliodent/C&B), with (A) no
covering materials, (B) toothpaste, or (C) kwik-cast.
Fig.3. Calcium and BOLD
responses under visual stimulation. (A) BOLD activation map (top
panel), stereotaxic coordinates of targeted regions for injecting GCaMP6f
(bottom panel). (B) LGd (n=3
scans), and (C) V1 (n=6 scans) activations, (D) Transfer
functions calculated from the averaged BOLD and calcium signals.