2928
HIGH RESOLUTION ODOR MAPPING IN AWAKE MOUSE OLFACTORY BULB USING CONTRAST ENHANCED FMRI
Christopher Cover1, Alexander Poplawsky1, Sujatha Nallama1, and Mitsuhiro Fukuda1
1Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States
Average motion during awake fMRI scans was 1/10th of a voxel, with ~5% of data exceeding a threshold of 25 µm. Activation maps of all four odors showed unique spatial patterns consistent with previously reported 2-deoxyglucose autoradiography studies.
Figure 1. Red-green-blue color coding of common and discrete CBVw-fMRI activations for each odor with baseline EPI underlay. Top 5% p-value threshold with a family-wise error correction of 30 minimum voxels in a cluster. (D – dorsal, V – ventral, R – right, L – left)
Figure 2. Motion characteristics of all awake fMRI scans. A) Histogram of all framewise displacement points with values exceeding a cut-off threshold of 25 μm (1/4 of a voxel) being highlighted in orange. B) Mean displacement per scan before and after motion censoring.