HIGH RESOLUTION ODOR MAPPING IN AWAKE MOUSE OLFACTORY BULB USING CONTRAST ENHANCED FMRI
Christopher Cover1, Alexander Poplawsky1, Sujatha Nallama1, and Mitsuhiro Fukuda1
1Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States
Average motion during awake fMRI scans was 1/10th
of a voxel, with ~5% of data exceeding a threshold of 25 µm. Activation maps of all four odors showed unique
spatial patterns consistent with previously reported 2-deoxyglucose
autoradiography studies.
Figure 1. Red-green-blue
color coding of common and discrete CBVw-fMRI activations for each odor with
baseline EPI underlay. Top 5% p-value threshold with a family-wise error
correction of 30 minimum voxels in a cluster. (D – dorsal, V – ventral, R – right,
L – left)
Figure 2. Motion characteristics of all awake fMRI
scans. A) Histogram of all framewise displacement points with values exceeding
a cut-off threshold of 25 μm
(1/4 of a voxel) being highlighted in orange. B) Mean displacement per scan
before and after motion censoring.