Rita Gil1, Frederico Severo1, and Noam Shemesh1
1Champalimaud Centre for the Unknown, Lisbon, Portugal
1Champalimaud Centre for the Unknown, Lisbon, Portugal
Our findings reveal increase monocular cortical BOLD responses upon dark rearing, in particular in the binocular subregion of the primary visual cortex. This suggests a lack of visual pathway maturation and binocular integration.
Fig.2: BOLD t-maps. TOP: Normal reared animals (N=7, 15 runs); BOTTOM: Dark reared animals (N=6, 16 runs). A significance value of 0.001 (FDR corrected) with minimum cluster size of 20 voxels was used in the generation of the maps. Blue arrows are pointing to the contralateral V1B region while yellow arrows are pointing to the contralateral lateral geniculate nucleus of the thalamus.
Fig.3: Cortical average cycle. Percent signal change (mean ± s.e.m) of (A) Contralateral VC; (B) Ipsilateral VC; (C) Contralateral V1B; (D) Ipsilateral V1B. Orange curves represent results from normal reared animals while black curves represent results for dark reared animals. Blue shaded region represents the stimulation period.
