Monica van den Berg1, Mohit Adhikari1, Georgios A. Keliris1, and Marleen Verhoye1
1Bio-Imaging Lab, University of Antwerp, Wilrijk, Belgium
1Bio-Imaging Lab, University of Antwerp, Wilrijk, Belgium
We observe spatiotemporal alterations in whole
brain network activity, predominantly in the basal forebrain and cingulate
cortex in 4-month old TgF344-AD rats. This indicates a potential signature to identify
early onset changes at the network level.
Changes in Quasi-periodic patterns in 4M old TgF344-AD rats. A) One-sample T-test maps of representative QPPs (rQPPs) for wild-type (WT) and transgenic (Tg) rats. Colors represent T-values (FDR corrected, p<0.05). B) Two sample t-test, reveals spatial differences between WT and TG animals, mainly in the basal forebrain (BFB) and Cingulate cortex (Cg). The colorbar indicates differences in T-values (FDR corrected, p<0,05). C) Average bold signal during QPP1 in the Cg (red), Somatosensory cortex (SS)(blue) and BFB (green). Both graphs show the mean +/- SEM (****p<0.0001)