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Cerebellar changes in Spinocerebellar Ataxia Type 2 and 12 in comparison with healthy controls
Pankaj pankaj1, S Senthil Kumaran1, and Achal Kumar Srivastava2
1NMR, All India Institute of Medical Sciences, New Delhi, India, 2Neurology, All India Institute of Medical Sciences, New Delhi, India
White and grey matter atrophy in SCA2 with respect to SCA12, and bilateral cerebellar atrophy in SCA in comparison with healthy controls correlate with tremor and gait abnormality.
Figure 1: Cerebellum atrophy in comparison of(a) HC and SCA2 (b)HC and SCA12 (c) SCA2 and SCA12 at the significant level of p<0.001, uncorrected (t-test) displayed on SUIT Flatmapview(color map: jet and threshold 0:0.1)
Table 1. Significant difference in the white matter between SCA2 and SCA12 (analysis using SUIT, one way ANOVA, p<0.05 FWE, voxel threshold (k)≥5)