Ting-Chieh Chen1, Yu-Chun Lo2, Yi-Chen Lin1, Ssu-Ju Li1, Ting-Chun Lin1, Ching-Wen Chang1, Yao-Wen Liang1, Hsiao-Chi Chuang3, and You-Yin Chen1,2
1Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan, 2Ph.D. Program for Neural Regenerative Medicine, Taipei Medical University, Taipei, Taiwan, 3School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan
1Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan, 2Ph.D. Program for Neural Regenerative Medicine, Taipei Medical University, Taipei, Taiwan, 3School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan
Our findings provided the brain MRI tractographic and behavioral evidences indicating the negative impacts of the traffic-related PM on motor functions as the possible associations with the development of PD.
Figure 1. Experimental design for investigating the effects of PM. According to the living condition, three experimental groups were established, including a control group, HEPA group and PM group. The tractography analysis and the rotarod performance test were conducted to respectively examine the effects of PM on the structural changes within rat brains and the motor-behavioral performances.
Figure 2. Whole-brain in-vivo DTI tractography. Based on the function of the neural circuits, DTI tractography analysis was conducted with the ROIs divided into the following three groups, including (A) the olfactory circuit, (B) motor control circuit and (C) dopaminergic pathway.