3122
Compact MRI bioreactor for real-time monitoring 3D printed tissue-engineered constructs.
Jean-Lynce GNANAGO1,2,3,4,5,6, Tony GERGES1,2,3,4,5,6, Laura Chastagnier1,2,4,6,7,8,9,10, Emma Petiot2,4,6,7,8,9,10, Vincent SEMET1,2,4,5,6, Philippe Lombard1,2,3,4,5,6, Christophe Marquette1,2,4,6,7,8,9,10, Michel Cabrera1,2,3,4,5,6, and Simon Auguste Lambert1,2,3,4,5,6
1Université Claude Bernard Lyon 1, VILLEURBANNE, France, 2INSA LYON, VILLEURBANNE, France, 3Ecole Centrale Lyon, Ecully, France, 4CNRS, VILLEURBANNE, France, 5AMPERE UMR 5005, VILLEURBANNE, France, 6Université de Lyon, VILLEURBANNE, France, 73d.FAB, VILLEURBANNE, France, 8CPE Lyon, VILLEURBANNE, France, 9ICBMS, VILLEURBANNE, France, 10UMR 5246, VILLEURBANNE, France
An MRI bioreactor is built using novel 3D printing techniques and plastronics. The integration of an MRI probe function within the bioreactor opens up possibilities of real time monitoring in the tissue engineering field.
Figure 1: Design and conception of the bioreactor. (A) 3D model of the bioreactor and its support. (B) Detailed view of the bottom of the 3D coil circuit and its integration. (C) Detailed view of the top of the 3D coil circuit and its integration
Figure 3: (A) Picture of the bioprinted tissue after construction. (B) 2D TURBO RARE image of the tissue using the bioreactor acquired on a 7T MRI scanner with a 75 µm in plane resolution.