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Spinal Giant Cell Tumor of Bone: Immunohistochemistry and Preoperative Magnetic Resonance Imaging Features for Prognostic Prediction

Qizheng Wang¹, Siyuan Qin¹, Yang Zhang², Enlong Zhang³, Xiaoying Xing¹, Min-Ying Su², and Ning Lang¹
¹Radiology, Peking University Third Hospital, Beijing, China, ²Center for Functional Onco-Imaging, Irvine, CA, United States, ³Radiology, Peking University International Hospital, Beijing, China

For patients with spinal GCTB, preoperative MRI observed multiple cystic changes and vertebral compression≥ 50%, suggesting a poor prognosis. The expression of vascular endothelial growth factor and p53 tumor suppressor gene may not be associated with postoperative recurrence.

Fig. 1. Flowchart of the enrolled patients. GCTB, giant cell tumor of bone; MRI, magnetic resonance imaging; TES, total en bloc spondylectomy.

Fig.2. Top panel: A 35-year-old man,(A) and (B): MR images showed a mass on the T12 vertebra, bilateral pedicle and lamina with extension into the spinal canal, managed with en bloc resection (C), at a 36-month follow-up review, there was no evidence of recurrence (D), and now the patient is still on visit.

Bottom panel: A 35-year-old woman, maximum diameter of lesion is 55mm (E),with pathologic fracture of the T12 vertebra (F) , managed with en bloc resection (G). The sagittal T2-WI MR image at 12-month follow-up, recurrence was detected (H), and confirmed by pathology with puncture.