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Proton lung ventilation MRI in cystic fibrosis: comparison with hyperpolarized gas MRI, pulmonary function tests and multiple-breath washout

Bilal A Tahir^1,2, Laurie J Smith¹, Joshua R Astley^1,2, Michael Walker¹, Alberto M Biancardi¹, Guilhem J Collier¹, Paul J Hughes¹, Helen Marshall¹, and Jim M Wild¹
¹POLARIS, University of Sheffield, Sheffield, United Kingdom, ²Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom

This study compares surrogates of regional ventilation, derived from inspiratory and expiratory 3D proton MRI with hyperpolarized gas MRI, pulmonary functions tests and multiple-breath washout, in patients with a broad range of cystic fibrosis disease severity and age.

Figure 1. Workflow of spatial comparison method of ¹H and ³He MRI ventilation.

Figure 2. Corresponding coronal slices for three patients of ³He (top row)) and ¹H (bottom row) MRI ventilation after registration. The red arrows depict defects and regions that are visually similar on both scans. Voxel-wise Spearman's correlation coefficients (ρ) are provided for each case.