William J Garrison1, G Wilson Miller1,2, Kun Qing2, Y Michael Shim3, Jaime F Mata2, Mu He3, Talissa A Altes4, Joanne M Cassani4, Sarah E Struchen2, Roselove N Nunoo-Asare2, Nicholas J Tustison2, Alan M Ropp2, and John P Mugler III1,2
1Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, 2Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States, 3Medicine, University of Virginia, Charlottesville, VA, United States, 4Radiology, University of Missouri, Columbia, MO, United States
1Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, 2Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States, 3Medicine, University of Virginia, Charlottesville, VA, United States, 4Radiology, University of Missouri, Columbia, MO, United States
Strong tissue-to-gas and RBC-to-tissue repeatability was
found in same-day dissolved-phase 129Xe MRI scans in healthy and COPD
subjects, and regressing out scan-to-scan lung volume changes improved
repeatability further.
Fig. 1. Second measurements vs. first measurements of tissue-to-gas, RBC-to-gas, and RBC-to-tissue, in healthy subjects (blue) and in COPD subjects (red), as well as intraclass correlation coefficient (ICC), coefficient of variation (CV), and coefficient of repeatability (CR) for each of the three gas uptake measures.
Fig. 3. Percent change in gas uptake ratios vs. percent
change in lung volume, for healthy subjects (blue) and COPD subjects (red),
with linear fits to all subjects (black line), healthy subjects (blue line),
and COPD subjects (red line), as well as correlation coefficients ρ,
slopes, and y-intercepts for each of the fits.