Marta Tibiletti1, Jo Naish1,2, John C Waterton1,3, Paul JC Hughes4, James A Eaden4, Jim M Wild4, and Geoff JM Parker1,5
1Bioxydyn Ltd, Manchester, United Kingdom, 2MCMR, Manchester University NHS Foundation Trust, Manchester, United Kingdom, 3Centre for Imaging Sciences,, University of Manchester, Manchester, United Kingdom, 4POLARIS, Imaging Sciences, Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, United Kingdom, 5Centre for Medical Image Computing, University College London, London, United Kingdom
1Bioxydyn Ltd, Manchester, United Kingdom, 2MCMR, Manchester University NHS Foundation Trust, Manchester, United Kingdom, 3Centre for Imaging Sciences,, University of Manchester, Manchester, United Kingdom, 4POLARIS, Imaging Sciences, Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, United Kingdom, 5Centre for Medical Image Computing, University College London, London, United Kingdom
In this work, we explore the possibility of extracting
a population Arterial Input Function from the pulmonary arteries to be used in the quantification of lung perfusion using
T1-weighted contrast
agent-based perfusion imaging, in cases where the measured AIF cannot be reliably extracted.
Figure 1: obtained population AIF, with AUC normalised
to 1. Gray shaded area indicates the ± standard
deviation area.
Figure 4: examples of blood volume (first row), MTT (second
row) and blood flow (third row) calculated using an individually-measured AIF (left)
and the population AIF (right) in a 52 years old male patient affected by
CTD-ILD.