Synthetic MRI with quantitative mappings as biomarkers for prediction of prognostic factors and molecular subtypes of breast cancer
Weibo Gao1, Quanxin Yang1, Xin Chen1, and Xiaocheng Wei2
1Radiology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China, 2MR Research, GE Healthcare, Beijing, China
Synthetic MRI parameters can be used as quantitative imaging biomarkers for the different receptor status of breast cancer. SD of PD-Pre, SD of PD-Gd, T2-Pre and T2-Gd were significantly different among molecular subtypes.
Figure 1: A 58-year-old woman with invasive ductal carcinoma of the right breast. An example of the synthetic images obtained before contrast agent injection. (a) T2(synthetic); (b) PD map; (c) T1 map; (d) T2map. The ROI showed the quantifications: T1-Pre = 1.71 10-3ms, SD of T1-Pre = 0.19, T2-Pre = 80.00 ms, SD of T2-Pre = 4.00, PD-Pre = 59.00 pu and SD of PD-Pre = 2.50 in this ER-positive, PR-negative, HER2-negative and Ki-67 high proliferating tumor.
Note. Data are mean ± standard deviation. P values less than .05* were considered to indicate statistical significance.