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Distinction of T2 quantitative measurements between the nucleus pulposus and anulus fibrosus using Gaussian-fitted histogram analysis
Xiaoqing Liang1, Weiyin Vivian Liu2, Jingyi Wang1, and Xiaoming Li1
1Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2MR Research,GE Healthcare, Beijing, China
Gaussian-fitted histogram analysis of T2 relaxation time could achieve quantitative measurement of the distinction between the nucleus pulposusand anulus fibrosus, and Gaussian-fitted histogram parameters have good performance in diagnosing and staging disc degeneration.

Figure.1 T2 histograms and Gaussian distributions of AF and NP.

a-e: Pfirrmann grade I-Ⅴ discs. The peak value of the NP gradually decreased and shifted towards the peak of the AF with the increasing grades.

f: The peak value of the NP was significantly lower than the AF of grade Ⅳ disc.

Figure.3 Receiver operating characteristic (ROC) curves analysis of all quantitative parameters for distinguishing healthy discs from degeneration ones.