Victor Fritz1, Petros Martirosian1, Jürgen Machann1,2, Rolf Daniels3, and Fritz Schick1
1Section on Experimental Radiology, University of Tübingen, Tübingen, Germany, 2Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany, 3Institute of Pharmaceutical Technology, University of Tübingen, Tübingen, Germany
1Section on Experimental Radiology, University of Tübingen, Tübingen, Germany, 2Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany, 3Institute of Pharmaceutical Technology, University of Tübingen, Tübingen, Germany
Development of oil-in-water emulsions for tissue simulation in MRI. Three different emulsifiers were examined for their MR-properties and their ability to stabilize an oil-water emulsion model. In this work, soy lecithin has been determined to be the most suitable emulsifier for use in MRI.
Figure 1: T2-maps of oil-in-water emulsions - acquired at different times after preparation. Assignment of the samples from the left to right: emulsion without emulsifier, stabilized by polysorbate, stabilized by lecithin, stabilized by SDS.
Figure 3: (a) T1 relaxation time and (b) T2 relaxation time of distilled water as a function of emulsifier concentration for polysorbate (blue) and lecithin (red).