Endre Grøvik1,2, Elisabeth Lysvik1, Robin Bugge1, Kyrre Emblem1, Trine Hjørnevik1, Svein-Are Vatnehol1, and Tryggve Storås1
1Oslo University Hospital, Oslo, Norway, 2University of South-Eastern Norway, Drammen, Norway
1Oslo University Hospital, Oslo, Norway, 2University of South-Eastern Norway, Drammen, Norway
We have developed an MRI glymphatic flow phantom with regions that mimics CFS-filled perivascular and vascular
spaces. This facilitates testing of MRI flow sequences in a controlled environment for
optimization of scans to allow
accurate measurements of glymphatic flow in the human brain.
Schematic illustration of the ultra-slow flow phantom mimicking
CFS-filled PVSs (a), and the experimental setup (b).
Visualization
of flow in the simulated perivascular space with two different flow rates:
approx. 65 µm/s
(a) and approx. 130 µm/s.
The images were acquired using a DWI TSE sequence and without pulsatile flow in
the simulated vascular space (inner tube).