Beni Mulyana1,2, Aki Tsuchiyagaito1, Jared Smith1, Masaya Misaki1, Samuel Cheng2, Martin Paulus1, Hamed Ekhtiari1, and Jerzy Bodurka1
1Laureate Institute for Brain Research, Tulsa, OK, United States, 2Electrical and Computer Engineering, University of Oklahoma, Tulsa, OK, United States
1Laureate Institute for Brain Research, Tulsa, OK, United States, 2Electrical and Computer Engineering, University of Oklahoma, Tulsa, OK, United States
Online optimization of tACS stimulation enhances
fronto-parietal connectivity, also selectively improves working memory in
healthy group as compared to control group. This study supports feasibility of
concurrent tACS-fMRI stimulation and measurement.
Overview of the closed-loop
tACS-fMRI-tACS runs. Training 1 and 2 on the experimental subject will find the
tACS parameters (frequency and phase) with the highest frontoparietal
connectivity. Otherwise, training 1 and 2 on the control subject will find the
tACS parameters (frequency and phase) with the lowest frontoparietal
connectivity.
a. On testing – training1 average, The experimental group showed higher improvement of frontoparietal connectivity rather than control group [experimental group: mean=0.06, SD=0.09; control group: mean=-0.1, SD=0.06; t(9)=3.31, p=0.009]. b. On the same measurement (testing – training1 average), the experimental group showed higher improvement of 2-back task accuracy rather than control group [experimental group: mean=6.02, SD=3.96; control group: mean=-2.41, SD=7.95; t(9)=2.30, p=0.047].
