Hyerin Oh1,2, Ben Babourina-Brooks1,2,3, Adam Berrington2,3, Dorothee P Auer1,2,3, Henryk Faas1,2, and JeYoung Jung4
1Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 2Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 3NIHR Nottingham Biomedical Research Centre, Queen’s Medical Centre, University of Nottingham, Nottingham, United Kingdom, 4School of Psychology, University of Nottingham, Nottingham, United Kingdom
1Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 2Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 3NIHR Nottingham Biomedical Research Centre, Queen’s Medical Centre, University of Nottingham, Nottingham, United Kingdom, 4School of Psychology, University of Nottingham, Nottingham, United Kingdom
Working memory task increased Glx concentrations in the DLPFC. Dynamic changes of Glx were associated with increased regional activity in the DLPFC as well as task performance in working memory.
Figure 2. (a), (d), (g) individual difference of Glx, GABA+, EIB in each condition (resting, 0 back, 2 back). (b), (e), (h) averaged relative Glx, GABA+, EIB change by T1. (c), (f), (i) dynamic relative Glx, GABA+, EIB change by T1. * p < 0.05
Figure 3. (a) fMRI results: 2-back > 0-back. A green box indicates the region of Interest (ROI) placement. (b) BOLD signal changes during 0 back and 2 back in the DLPFC ROI. (c) A positive correlation between signal change during 2-back and Glx changes (2-back > 0-back). (d) A negative correlation between 2-back task accuracy and Glx changes (2-back > 0-back). (e) A positive correlation between 2-back task response time and Glx changes (2-back > 0-back). *** p <0.001
