3437
A novel clinically viable method to quantify T2 of intra and extra axonal compartmental tissue properties
Sudhir Kumar Pathak1, Vishwesh Nath2, B V Rathish Kumar3, and Walter Schneider1
1Psychology, University of Pittsburgh, Pittsburgh, PA, United States, 2Nvidia, Bethesda, MD, United States, 3Mathematics, Indian Institute of Technology Kanpur, Kanpur, India
We have proposed an extended SMT framework to estimate intra and extra-axonal T2 along with volume fraction and axial and radial diffusivity. A numerical framework is also presented to estimate all parameters for a typical multi-shell diffusion protocol.
Axial Slice of intra and extra-axonal T2. Higher values in the internal capsule show highly myelinated axons.
Axial Slice of intra-axonal volume fraction. Estimated intra-axonal volume shows a clear segmentation of white matter tissue that is consistent with SMT model.