Dipak Roy1 and Anant Bahadur Patel1
1NMR Microimaging and Spectroscopy Facility, Centre for Cellular and Molecular Biology, Hyderabad, India
1NMR Microimaging and Spectroscopy Facility, Centre for Cellular and Molecular Biology, Hyderabad, India
In this study, we investigated the
neurometabolic and astroglial activity in the SOD1G37R mouse model
of ALS. Our findings suggest reduced neuronal and increased astroglial activity
in the spinal cord. However, the activities of astroglia and neurons were elevated
in the cerebral cortex.
Figure 3: Cerebral Metabolic rates of glucose oxidation (CMRGlc(Ox))
in A. Cerebral cortex and B. Spinal cord. The
bar graph represents the mean±SD of the group.
Figure 4: Cerebral Metabolic rates of acetate oxidation (CMRAce(Ox))
in A. Cerebral cortex and B. Spinal cord. The
bar graph represents the mean±SD of the group.