Mengsha Zou1, Hongzhang Zhu1, Yunzhu Wu2, and Zhiyun Yang1
1Radiology, The first affiliated hospital of Sun Yet-sen University, Guangzhou, China, 2MR Sicentific Marketing, Siemens Healthineers, Shanghai, China
1Radiology, The first affiliated hospital of Sun Yet-sen University, Guangzhou, China, 2MR Sicentific Marketing, Siemens Healthineers, Shanghai, China
Dysthyroid optic neuropathy (DON) is one of the most severe types of Graves orbitopathy (GO) and frequently difficult to diagnose clinically in its early stages. In our study, we evaluate orbital condition of DON patients by using quantitative multimodal MRI.
FIG.1.Methods for measurement of mMI and mean T2 value in a 53-year-old patient with bilateral DON (top row) and a 50-year-old GO patient without DON(bottom row). Axial fat-suppressed T2-weighted images in orbit with DON(A) and without DON(B). Oblique coronal T2WI of Dixon show mMI at 21mm with DON(C) and without DON(D) [mMI was the maximum value between (a+b)/c and (d+e)/f)]. E.F Coronal T1WI was presented as anatomical reference. T2 value of optic nerve of the eye with DON was 207.3ms(G) and the eye without DON was 105.5ms(H) respectively.
FIG.2. MRI indicators for prediction of DON.Receiver operating characteristic curve analysis(A) and decision curve analysis (B) showed that combination of mMI at 21mm and optic nerve mean T2 value demonstrated optimal diagnostic efficiency for DON.