Abdullah S. Bdaiwi1,2, Peter J. Nedbalski1, Md M. Hossain3, Matthew M. Willmering1, Laura L. Walkup1,2,4, Hui Wang5, Robert P. Thomen1, Kai Ruppert1, Jason C. Woods1,4,6, and Zackary I. Cleveland1,2,4,6
1Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2Biomedical Engineering Department, University of Cincinnati, Cincinnati, OH, United States, 3Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 4Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 5Philips, Cincinnati, OH, United States, 6Department of Pediatrics, University of Cincinnati, Cincinnati, OH, United States
1Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2Biomedical Engineering Department, University of Cincinnati, Cincinnati, OH, United States, 3Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 4Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 5Philips, Cincinnati, OH, United States, 6Department of Pediatrics, University of Cincinnati, Cincinnati, OH, United States
Data acquisition and analysis of HP 129Xe diffusion imaging can be optimized using an analytical model, prior
knowledge of ADC (age-dependent) and Bayesian fitting, thus providing ADC
measures that best reflect microstructural changes during lung disease
progression and therapy response.
Fig. 1. (a) Uncertainty in ADC measurements.
(b) A clear decrease in the relative
uncertainty, 𝝐ADC, is observed with increasing SNR0. (c) Shows the decrease of 𝝐ADC as Nph
decreases across the ADC range, where this decrease is more
pronounced for very small and very large ADC values. (d) Shows the increase of 𝝐ADC as Nb
increases across the ADC range with global minima at Nb≤4. However, for large 129Xe ADC (>0.06 cm2/s)
using only 2 b-values increases the relative error significantly. (e) Shows the global minima of at Mz(R)=20% across the ADC range.
Fig. 4. In vivo HP 129Xe ADC
mapping. (a) b0
image alongside with (b) ADC maps of a 6, 18 and 30 years old healthy
subjects [Note: The b0 images and the ADC maps were interpolated for
visualization only]. (c) Corresponding ADC histograms obtained from the
subjects imaged in a. Mean ADC increases noticeably with aging in these
subjects.
