Andre Monteiro Paschoal1,2, Raquel Andrade Moreno3,4, Antonio Carlos dos Santos5, and Renata Ferranti Leoni6
1LIM44, Instituto e Departamento de Radiologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil, 2InBrain Lab, University of Sao Paulo, Ribeirao Preto, Brazil, 3Instituto do Cancer do Estado de Sao Paulo, Sao Paulo, Brazil, 4Memorial Sloan-Kettering Cancer Center, New York, NY, United States, 5Departamento de Clinica Medica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Brazil, 6InBrain Lab - University of Sao Paulo, Ribeirao Preto, Brazil
1LIM44, Instituto e Departamento de Radiologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil, 2InBrain Lab, University of Sao Paulo, Ribeirao Preto, Brazil, 3Instituto do Cancer do Estado de Sao Paulo, Sao Paulo, Brazil, 4Memorial Sloan-Kettering Cancer Center, New York, NY, United States, 5Departamento de Clinica Medica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Brazil, 6InBrain Lab - University of Sao Paulo, Ribeirao Preto, Brazil
IVIM fD* maps were able to detect small perfusion changes in early stages of low grade gliomas, suggesting its use as an early biomarker for this parameter. In high grade glioma, it may provide complementary information to contrast agent perfusion.
Figure 1: High grade glioma. a) DSC CBF map; b) IVIM fD* map; c) SWI map; d) Correlation between fD* and CBF at the tumor ROI in yellow at the tumor border; e) Correlation between fD* and CBF at the tumor ROI in green at the tumor interior.
Figure 2: Low grade glioma. a) DSC CBF map; b) DSC CBV map; c) IVIM fD* map; d) FLAIR; e) Post contrast T1 image; f) SWI; g) Correlation between fD* and CBF at the tumor ROI at the tumor border; h) Correlation between fD* and CBF at the tumor ROI at the tumor interior.