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Comparison of Capability for Molecular-Based Assessment between 3D Gradient Echo-Based and 2D Spin Echo-Based CEST Imaging for Brain Tumors
Kazuhiro Murayama1, Yoshiharu Ohno2, Masao Yui3, Kaori Yamamoto3, Masato Ikedo3, Satomu Hanamatsu2, Akiyoshi Iwase4, Takashi Fukuba4, and Hiroshi Toyama2
11) Joint Research Laboratory of Advanced Medical Imaging, Fujita Health University School of Medicine, Toyoake, Japan, 2Radiology, Fujita Health University School of Medicine, Toyoake, Japan, 3Canon Medical Systems Corporation, Otawara, Japan, 4Radiology, Fujita Health University Hospital, Toyoake, Japan
3D chemical exchange saturation transfer (CEST) imaging has equal to or higher potentials for molecular-based assessment and can be considered at least as valuable as 2D CEST imaging in patients with various brain tumors.

Figure 1. 50-year old male with glioblastoma (Grade Ⅳ).

Glioblastoma (arrow) is shown in the left temporal cerebral suubcortical and white matter on Fluid-attenuated inversion recovery (FLAIR), Contrast-enhanced T1-weighted imaging (CE-T1WI) and CEST imaging. 3D CEST imaging can cover the whole lesion as compared with 2D CEST imaging. MTRasym at 3.5ppm in this case were 2.12% (2D CEST imaging) and 1.69% (3D CEST imaging). 2D and 3D CEST imaging were diagnosed as glioblastoma (grade Ⅳ).

Figure 2. Results of correlation and Bland-Altman plot analysis between 2D and 3D CEST imaging measurement of MTRasym (at 3.5 ppm) for all lesions.

3D CEST imaging had significant and excellent correlation with 2D CEST imaging (r=0.80, p<0.0001). The limits of agreement between 2D and 3D CEST imaging was -0.012±0.73 (mean±1.96 × standard deviation) %.