Tao Gong1, Yufan Chen1, Liangjie Lin2, Youting Lin3, and Guangbin Wang1
1Shandong Medical Imaging Research Institute, Shandong University, Jinan, China, 2Philips Healthcare, Beijing, China, 3Departments of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China
1Shandong Medical Imaging Research Institute, Shandong University, Jinan, China, 2Philips Healthcare, Beijing, China, 3Departments of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China
The results of this study indicated that GABAergic inhibition
enhanced in FCD foci of epilepsy patients, while no significant alteration of
GSH and Glx levels was found, suggesting GABA may
play a central role in the pathophysiology of FCD-associated epilepsy.
Figure
1.
T2-FLAIR image (a) of an FCD (white arrow) -associated epilepsy patient, the
volumes of interest of HERMES in the patient (b and c) and in a matched healthy
control (d). The mean (± standard deviation) GABA (e), Glx (e) and GSH (f)
-edited spectra from the HERMES sequence in FCD foci, contralateral regions and
healthy controls.
Figure 2. Comparation of GABA, GSH and Glx
levels between the FCD foci, contralateral regions and healthy controls using
ANOVA, and the results indicated that GABA levels was
significantly increased in FCD foci compared with contralateral regions
(p=0.007) and with healthy controls (p=0.003).