The value of GRASP DCE-MRI for the differentiation between benign and malignant endometrium lesions
yaling wang1, Zhongshuai Zhang2, Yuancheng Wang1, and Shenghong Ju1
1Zhongda Hospital,School of Medicine,Southeast University, NanJing, China, 2SIEMENS Healthcare, Shanghai, China
This prospective study
aimed to investigate the value of GRASP(Golden-angle RAdial Sparse Parallel)on dynamic gadolinium-enhanced T1-weighted MRI(DCE-MRI)for differentiation between benign and malignant
lesions of endometrium on 88 patients.
Figure
3. A 71-year-old female with endometrial carcinoma. ROI was placed in endometrial
carcinoma area and superficial myometrial area. Both A-C and E-G are the Ktrans,
Kep and iAUC, respectively, D and H were DCE concentration curves of
the mass and superficial myometrial layer. The calculated Ktrans, Kep
and and Ve values of the mass
were:0.085 min−1, 0.646 min−1, 0.131, respectively. The
Ktrans, Kep and and Ve values of the superficial myometrial layer were:0.31 min−1,
0.981 min−1, 0.316, respectively.
Figure
1. The Kep distribution of benign and malignant endometrium lesions.
The mean Kep values of these two group of statistical measurements
are: benign: 0.627 ± 0.673min−1and malignant: 1.412 ± 1.143 min−1
(T test, p<0.01). The area under the ROC curve of Kep value is 0.82 which indicates
that the Kep values have very good predictive ability for differentiation
between benign
and malignant endometrium lesions