Inhibition of Urine Amide Proton Transfer Signal with Optimal Scan Parameters in Bladder Cancer
Bo Dai1, Meiyun Wang 1, Fengshan Yan1, Zhiwei Shen2, Yan Bai1, and Nan Meng1
1Henan Provincial People's Hospital, Zhengzhou, China, 2Philips healthcare, Beijing, China
In this preliminary study, we found that APTw signal increased with elevated concentrations of urea in phantoms. With the optimal scan parameters, the higher APTw contrast in bladder lesions was acquired, which is helpful to differentiate different grading of bladder cancer with APTw imaging.
The upper four tube showed the averaged signal intensity of APTw with urea of the concentration of 2 %, 4 %, 6 %, 8 % were 1.07%, 2.46%, 4.78%, 7.22%;the lower four tubes showed in water, egg white ,a healthy volunteer and a patient with bladder cancer were -0.38% ,8.25% 3.13% and 0.29%.