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Effectiveness of split dose of gadoterate meglumine injection using 30% and 70% of standard dose to detect prostate cancer using ultrafast DCE-MRI

Xiaobing Fan¹, Aritrick Chatterjee¹, Jay M Pittman¹, Ambereen Yousuf¹, Tatjana Antic², Gregory S Karczmar¹, and Aytekin Oto¹
¹Radiology, The University of Chicago, Chicago, IL, United States, ²Pathology, The University of Chicago, Chicago, IL, United States

A split dose protocol for Dotarem injection with ultrafast DCE-MRI sampling can improve detection of prostate cancer by improving quantitative analysis and providing sensitivity to water exchange.

Figure 1. Plots of blood S_br(t) (dots) obtained from iliac artery and its EMM fits (line) for (a) 30% of standard dose and (b) 70% dose of standard dose. (c) and (d) show plots of cancer and tissue S_r(t) (dots) and their fits (lines) obtained from the SI-Tofts model for (c) 30% and (d) 70% of standard dose.

Figure 2. Box-plots of cancer (red) and normal tissue (green) physiological parameters (a ,c) K^trans and (b, d) v_e extracted from SI-Tofts model for the 30% (top row) and 70% (bottom row) of standard dose DCE-MRI. The square (□) indicates mean and the asterisks (*) indicate the upper and lower limits of the data.