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Evaluation of Ultrafast Post-Contrast Wave-CAIPI 3D-T1 MPRAGE Compared to Standard 3D-T1 MPRAGE for Evaluating Enhancing Lesions on 3T MRI.

Augusto Lio M. Goncalves Filho^1,2, John Conklin^1,2, Chanon Ngamsombat³, Stephen F. Cauley², Wei Liu⁴, Daniel N. Splitthoff⁵, Wei-Ching Lo⁶, John E. Kirsch¹, Pamela W. Schaefer¹, Otto Rapalino¹, and Susie Y. Huang^1,2
¹Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, ²Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, ³Department of Radiology, Siriraj Hospital, Bangkok, Thailand, ⁴Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, ⁵Siemens Healthcare GmbH, Erlangen, Germany, ⁶Siemens Medical Solutions Inc., Boston, MA, United States

An accelerated post-contrast Wave-CAIPI 3D T1 MPRAGE sequence is non-inferior to the standard T1 MPRAGE for detection of intracranial enhancing lesions in 3T MRI while providing a 2-fold reduction in acquisition time and being less sensitive to motion artifacts.

Figure 2. Representative images showing a comparison of post-contrast Wave-CAIPI T1 MPRAGE and standard T1 MPRAGE sequences. (A) A 56-year-old male with brain metastases from squamous-cell carcinoma. (B) A 71-year-old male with brain metastases from non-small cell lung cancer.

Figure 1. Balloon plot showing the results of the head-to-head comparison of post-contrast standard T1 MPRAGE and post-contrast Wave-CAIPI T1 MPRAGE for visualization of abnormal intracranial enhancing lesions, the perception of noise, presence of artifacts due to motion, and the overall diagnostic quality. A zero-score indicates equivalency, negative scores (left) favor standard T1 MPRAGE, and positive scores (right) favor Wave-T1 MPRAGE.