Zungho Zun1,2,3,4, Kushal Kapse1, Nicole Andersen1, Scott Barnett1,2,3,4, Anushree Kapse1, Kristina Espinosa1, Jessica Quistorff1, Catherine Lopez1, Jonathan Murnick1,3,4, Mary T. Donofrio2,3,5, and Catherine Limperopoulos1,2,3,4
1Division of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, DC, United States, 2Division of Fetal and Transitional Medicine, Children's National Hospital, Washington, DC, United States, 3Department of Pediatrics, George Washington University, Washington, DC, United States, 4Department of Radiology, George Washington University, Washington, DC, United States, 5Division of Cardiology, Children’s National Hospital, Washington, DC, United States
1Division of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, DC, United States, 2Division of Fetal and Transitional Medicine, Children's National Hospital, Washington, DC, United States, 3Department of Pediatrics, George Washington University, Washington, DC, United States, 4Department of Radiology, George Washington University, Washington, DC, United States, 5Division of Cardiology, Children’s National Hospital, Washington, DC, United States
Magnetic susceptibilities measured in the first two months of life were lower in the white matter and temporal lobe in infants diagnosed with congenital heart disease, and Bayley language scores evaluated at 18 months were associated with magnetic susceptibilities of the temporal lobe.
Figure 1. Regional magnetic susceptibilities measured in the brain of healthy control infants and those diagnosed with CHD in the first two months of life. Asterisks denote significant differences between control and CHD infants when controlling for PMA and accounting for repeated measures of the same infant.
Table 2. Associations between magnetic susceptibilities measured in pre/post-operative MRI and Bayley-III receptive/expressive language scores. P values in bold indicate significant associations.
