Quantitative Magnetization Transfer MRI of the Knee Meniscus: Correlations with Biochemistry and Histology
Kirstin D Olsen1, Lumeng Cui1, Brennan E Berryman2, Ives R Levesque3, and Emily J McWalter2
1Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada, 2Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada, 3Medical Physics, McGill University, Montreal, QC, Canada
Quantitative
magnetization transfer MRI was investigated in human cadaver menisci and weak
correlations were found between T1f and the
collagen content, T1f and histology score, and the histology scores and T2f and T2b. A moderate
correlation was found between T2f and
collagen content.
Table 1:
Average qMT parameters (N=6 cadaver knee specimens) and biochemical content (N=70
excised cylindrical plugs). WM is wet mass
Table 2: Frequency and percentage of each grade
for human cadaver menisci samples (N=161). G1=normal tissue, G2=mild degeneration,
G3=moderate degeneration, G4=severe degeneration