Stefan Ruschke1, Jan Syväri1, Michael Dieckmeyer2, Daniela Junker1, Marcus R. Makowski1, Thomas Baum2, and Dimitrios C. Karampinos1
1Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany, 2Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Munich, Germany
1Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany, 2Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Munich, Germany
Vertebral bone marrow
water T2 assessed by single-voxel multi-TE STEAM MRS showed a significant
sex-dependence and a negative correlation with age and PDFF.
Figure 3: Results
from the linear regression analysis for the female (red) and male (blue)
sub-cohort for a) water T2 vs age, b) water T2 vs. PDFF and c) PDFF vs. age.
Water T2 as a function of both age (a) and PDFF (b) was longer in females when
compared to the males. Furthermore, water T2 showed a negative correlation with
both age (a) and PDFF (b) for both sexes.
Figure 2: Example real spectra including the obtained signal model fitting (fitted model and residual signal): a) 38-year-old female (BMI: 31.3 kg/m2, water T2: 33.3 ms, PDFF: 40%) and b) 66-year-old male (BMI: 38.6 kg/m2, water T2: 13.9 ms, PDFF: 49%). In the spectra in a) the water peak (4.67 ppm) is more pronounced (lower PDFF and shorter water T2) in comparison to the spectra in b).
