Towards Catheter-based Intra-Arterial Spin Labeling for Perfusion Measurements
Kevin Waescher1, Simon Reiss1, Ali Caglar Özen1,2, Thomas Lottner1, and Michael Bock1
1Dept. of Radiology, Medical Physics, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, 2German Consortium for Translational Cancer Research Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
In this study, we
present in vitro results to demonstrate that arterial spin labelling using a local catheter
based labelling coil provides an alternative technique for perfusion
measurements during cardiovascular interventions without the use of exogenous contrast
agents.
Figure 2: Frequency dependence
of the labelling signal fitted with a Lorentzian (a) along with the power dependence
(b). Image of the catheter (c) and map of the relative signal difference created
by the labelling (d). The difference image indicates the transmit B1 profile of
the labelling coil.
Figure 3: Image of the perfusion
phantom setup (a) and maps of the relative signal difference between the
labelled and unlabeled case for two different flow velocities (c and d). A plot of the normalized signal difference shows
the exponential decay within the perfusion phantom.