Tianxiao Zhang1, Rong Guo2,3, Tianyao Wang4, Zengping Lin1, Yudu Li2,3, Yibo Zhao2,3, Jun Liu4, Danhong Wu5, Zheng Jin6, Xin Yu7, Zhi-Pei Liang2,3, and Yao Li1
1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 2Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 3Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 4Radiology Department, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China, 5Neurology Department, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China, 6Shanghai Minhang Hospital of Integrated Traditional Chinese and Western Medicine Hospital, Shanghai, China, 7Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States
1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 2Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 3Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 4Radiology Department, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China, 5Neurology Department, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China, 6Shanghai Minhang Hospital of Integrated Traditional Chinese and Western Medicine Hospital, Shanghai, China, 7Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States
We performed high-resolution simultaneous measurements
of brain oxygenation and metabolism in acute stroke. Our results showed not
only the expected changes in the markers of oxygenation and neurometabolites
individually, but also their concurrent coupling.
Figure 1. Simultaneous 3D brain neurometabolites and OEF
mapping for an acute ischemic stroke patient. (A, B) 3D NAA and Lac map in
triplanar views overlaid on T1-weighted images. The representative spectra were
from the DWI lesion (red), infarct growth (blue) and contralateral normal
(light green) regions, respectively. (C) 3D venous OEF map in triplanar views
overlaid on QSM images. (D) 3D quantitative
map in triplanar views. (E)
Timeline of the experimental study.
Figure 4. Significant correlations between
values and lactate or lactate to NAA ratio
concurrently detected in infarct growth area (A) but not in infarct core (B) of
acute ischemic stroke patients.