Arun Joseph^1,2,3, Patrick Liebig⁴, Piotr Radojewski^2,5, Roland Wiest^2,5, Tobias Kober^6,7,8, and Tom Hilbert^6,7,8
1Advanced Clinical Imaging Technology, Siemens Healthcare AG, Bern, Switzerland, ²Translational Imaging Center, sitem-insel AG, Bern, Switzerland, ³Magnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland, ⁴Siemens Healthcare GmbH, Erlangen, Germany, ⁵Support Center for Advanced Neuroimaging, Institute for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University, Bern, Switzerland, ⁶Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁷Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ⁸LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

Vascular disease such as arteriovenous malformations can be fatal and lead to brain damage if not detected early. To that end, time of flight angiography is an important tool to visualize vessels, especially the arteries with implications for treatment planning and follow-up. Similarly, susceptibility weighted imaging can be used to visualize veins due to its sensitivity to magnetic field inhomogeneities. However, high resolution TOF and SWI acquisitions can lead to clinically unfeasible scan times. Here, we propose to use compressed-sensing-accelerated high resolution TOF and SWI acquisitions at 7T in <15 minutes to visualize the vascular system of the whole brain.

Wei Qiu¹, Hanyu Wei¹, Shuo Chen¹, and Rui Li^1
1Department of Medicine, CBIR, Tsinghua University, Beijing, China

Accurate and fast automatic Carotid artery segmentation of time of flight(TOF) MRA plays an important role in the auxiliary diagnosis of carotid artery disease. Considering the complexity and uncertainty of doctors’ manual segmentation of neck vessels, automatic segmentation algorithms are required in clinical practice. A segmentation model based on 3D Convolutional neural network (CNN) was proposed to segment carotid arteries from TOF MRA images. With innovative adjustment of the network architecture and parameters for carotid application, our model showed better performance than other baseline models on private dataset.

Mariya S. Pravdivtseva¹, Fritz Wodarg², Jana Korte³, Philipp Berg³, Jan-Bernd Hövener¹, Olav Jansen², and Naomi Larsen^2
1Department of Radiology and Neuroradiology, Section Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), University Medical Center Schleswig-Holstein (UKSH), Kiel University, Kiel, Germany, ²Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein (UKSH), Kiel, Germany, ³Research Campus STIMULATE, University of Magdeburg, Magderburg, Germany

Intracranial aneurysm is a life-threatening disease that can be treated with flow-modulating devices (FMDs) by reducing aneurysm blood flow. Aneurysms might rupture after treatment, thus biomarker of successful treatment is needed. Flow MRI can detect flow reduction, however, it is impaired by metal artifacts from FMDs. Black-blood (BB) MRI is less sensitive to metal artifacts and often results in poor slow-flow suppression. We hypothesize that BB contrast changes after aneurysm treatment. Here, after placing FMDs in 3D-printed aneurysm models, an enhanced signal was found on BB MRI, associated with reduced aneurysmal flow after flow modulation and thus possible treatment success.

Adam Goldman-Yassen^1,2, Vishal Patel³, Maria J. Borja³, Anna Derman⁴, Duan Chen⁵, Siddhant Dogra³, Roy Wiggins³, Kai Tobias Block³, and Seena Dehkharghani^3,6
1Department of Radiology, Children's Healthcare of Atlanta, Atlata, GA, United States, ²Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States, ³Department of Radiology, New York University Langone Medical Center, New York, NY, United States, ⁴Department of Radiology, Maimonides Medical Center, Brooklyn, NY, United States, ⁵Department of Radiology, Weill Cornell Medical Center, New York, NY, United States, ⁶Department of Neurology, New York University Langone Medical Center, New York, NY, United States

GRASP MRI obtained as part of routine clinical care, without specific angiographic parameters, can be reconstructed post-hoc into dynamic 4D MR images and can be displayed with high spatial and temporal resolution. Additionally, contrast dose and magnet strength appear to have minimal effect on the diagnostic quality of angiographic images. Further exploration into diagnostic accuracy and the tolerance of varying field strength and dosing to further increasing degrees of acceleration is warranted.

Eva Peschke¹, Mariya Pravdivtseva¹, Olav Jansen², Naomi Larsen², and Jan-Bernd Hövener^1
1Section Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology, University Medical Center Schleswig - Holstein, Kiel University, Kiel, Germany, Kiel, Germany, ²Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein, Kiel University, Kiel, Germany, Kiel, Germany

Vessel wall imaging (VWI) is a unique method to depict the vessel walls in vivo but was not applied in small animal models at 7T yet. Here, we developed a setup to emulate T₁ contrast and flow to optimize Black Blood MRI in vitro. Using the results, we implemented a RARE sequence that allows in vivo Black Blood MRI with a high resolution of 0.156 x 0.156 mm² and successful flow suppression. Next, the model will be extended for VWI to measure the enhancement of Gadolinium contrast agent.

hui hong¹ and minming zhang^2
1the second affiliated hospital of zhejiang university, school of medicine, hangzhou, China, ²radiology, the second affiliated hospital of zhejiang university, school of medicine, hangzhou, China

The enlargement of white matter perivascular space(PVS) is highly CAA related, however lack of studies investigated its role in stable pattern CSVD patients, we hypothesis that CSVD patients with white matter PVS enlargement indicates a CAA pattern changes.

Here we compared patients with and without white matter PVS enlargement from imaging manifestation, imaging mechanism and clinical cognitive ability. We foud that patients with PVS enlargenmet showed a pattern similar to previous symptomatic CAA, that  is more lobar microbleed, more interstitial fluid retention and significantly lower global cognitive ability. Extra dignosis and treament should be carried out to this pattern CSVD.

Yajing Zhang¹, Jilei Zhang², Maoxue Wang³, Kun Wang³, Xiance Zhao², Peng Wu², Weibo Chen², Queenie Chan², Johannes M. Peeters⁴, Marc Van Cauteren⁵, and Bing Zhang^3
1BU-MR Clinical Science, Philips Healthcare, Suzhou, China, ²Philips Healthcare, Shanghai, China, ³Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China, ⁴BU-MR Clinical Science, Philips Healthcare, Best, Netherlands, ⁵BU-MR Clinical Science, Philips Healthcare, Tokyo, Japan

MR angiography (MRA) in moyamoya disease has been uniquely important in the evaluation of changes in vasculature and brain parenchyma, and clinical follow-up. In this work, we investigate the performance of accelerated MRA under a deep learning constrained Compressed SENSE reconstruction framework. Results on both volunteer and patients demonstrate a three-fold scan acceleration against the routine MRA with comparable image quality.