Hongyi Li¹, Huang lesheng¹, Jun Chen¹, Weiyin Vivian Liu ², Jinghua Jiang¹, Kaili Cai¹, Tianzhu Liu¹, Wanchun Zhang¹, Jiahui Tang¹, Kailian Yang¹, Se Peng³, and Dan Li^4
1Radiology, Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, China, ²MR Research, GE Healthcare, Beijing, China, ³Clinical Lab, Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, China, ⁴Hepatology, Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, China

The purpose was to evaluate the feasibility of IDEAL-IQ in distinction of patients with early liver cirrhosis(compensated stage). Sixty CHB patients with compensated cirrhosis conformed by liver biopsy and twenty healthy controls were recruited. FF and R2^* of IDEAL-IQ sequence were analyzed between CHB compensated cirrhosis patients and volunteers. Correlations between FF and R2^* and ALT, INR values were analyzed in CHB patients with compensated cirrhosis. R2^* was statistically different between compensated cirrhosis patients and volunteers (p<0.01) with AUC of 0.726. The correlations between FF and ALT, INR were both fair(0.268, p=0.03 and -0.351, p<0.01).

nannan shi¹, jianqing sun², Fei Shan¹, Yiying qin¹, Zecheng yang¹, Weibo chen³, and yuxin shi^1
1Shanghai Public Health Clinical Center, Fudan University, shanghai, China, ²Shanghai United Imaging Research Institute of Intelligent Imaging, shanghai, China, ³Philips Healthcare, shanghai, China

To further develop and validate a radiomics-based model from liver T2WI images for staging liver fibrosis.

Huijian Lu¹, Hongmei Gu¹, Fangfang Shang¹, Li Yuan¹, Xinquan Wang¹, Weiqiang Dou², and Weiyin Vivian Liu^2
1Affiliated Hospital of Nantong University, Nantong, China, ²MR Research, GE Healthcare, Beijing, China

Renal T1 and R2* mapping were performed on 55 diabetic nephropathy (DN) patients , 20 healthy volunteers（HVs）and 10 diabetes mellitus (DM) patients to explore the clinical potential in assessing renal function. While comparable T1 and R2* values of renal cortex were found between HVs and DM patients, DN patients showed significantly increased T1 and R2* values of renal cortex relative to HVs and DM patients. Both T1 and R2*metrics were also significantly correlated with renal function. Therefore, quantitative T1 and R2* mapping might be considered effective measures in evaluating renal function for DN patients.

Pin Yang¹, YanLi Jiang¹, Jie Zou¹, Miao Chang¹, Jing Zhang¹, and Kai Ai^2
1Department of Magnetic Resonance, LanZhou University Second Hospital, Lanzhou, China, ²Philips Healthcare, Xi’an, China

This study evaluates the feasibility of extracellular volume fraction (ECV) in judging liver fibrosis, analyzes the interaction between ECV and liver function.The method is to calculate ECV in different degrees of liver function and compare the correlation between ECV and serum albumin. Our research shows that ECV20_min had no significant difference among Child-Pugh A, Child-Pugh B and Child-Pugh C, there was a weak correlation with serum albumin. Therefore, we consider that ECV of hepatobiliary phase will not be affected by liver function when Gd-EOB-DTPA is used to evaluate liver fibrosis, it may be a reliable tool in assessing liver fibrosis.

Yufei Zhao¹ and Xingui Peng^1
1Southeast University, Nanjing, China

The staging of chronic hepatitis B mainly relies on invasive pathological biopsy, interferon treatment can reduce the risk of deterioration. 93 patients were divided into three groups: mild, moderate, severe or liver cirrhosis according to histopathology and received T₁ρ magnetic resonance liver scan before and after interferon treatment. With the aggravation of chronic hepatitis B, T1ρ relaxation time gradually increased, but it decreased significantly after treatment, which is linearly correlated with the level of ALT and AST. T₁ρ magnetic resonance can non-invasively assess the severity of the chronic hepatitis B and monitor the improvement of fibrosis after receiving treatment dynamically.

Po-Ting Chen^1,2, Cheng-Ya Yeh², Yi-Chen Chen², Chia-Wei Li³, Charng-Chyi Shieh³, Chien-Yuan Lin³, and Kao-Lang Liu^1,2
1Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ²Department of Medical Imaging, National Taiwan University Cancer Center, Taipei, Taiwan, ³GE Healthcare, Taipei, Taiwan

There has been no study that demonstrated the quality improvement in abdomen images by DLrecon. We evaluate the image quality comparison, included SNR, CNR, and clinical scoring, between DL and non-DL abdomen images. DLrecon are found to be less artefacts, higher SNR, CNR, and clinical scores than those on non-DL images. This study proves the improvement of image quality by DLrecon, and DLrecon shows its potential power in clinical diagnosis of abdomen images to overcome classical MRI trade-off resolution, SNR, and scan time.

Wang Nan^1,2,3, Huang Jisui², Song Qingwei¹, Chen Lihua¹, Lei Na³, and Liu Ailian^1
1the First Affiliated Hospital of Dalian Medical University, Dalian, China, ²Capital Normal University, Beijing, China, ³Dalian University of Technology, Dalian, China

The normal liver is affected by various pathogenic factors, resulting in liver fibrosis, progressive disease, false lobule formation and cirrhosis. Liver cirrhosis will be accompanied by morphological changes of liver. Literature studies have shown that liver surface nodularity can be used to evaluate the progress of liver cirrhosis and predict the stage of liver cirrhosis. The method of curvature analysis of liver surface nodules adopted by our team is feasible and can be used to evaluate early cirrhosis.

Wang Nan¹, Lihua Chen¹, Qingwei Song¹, Jiazheng Wang², Zhigang Wu², and Liu Ailian^3
1Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian, China, ²Philips Healthcare, Beijing, China, ³the First Affiliated Hospital of Dalian Medical University, Dalian, China

Evaluation of liver reserve function is crucial for patients with cirrhosis and is helpful for the determination of the surgical plan formulation, the evaluation of treatment process and prognosis, and the operation of cirrhosis. However, there is still lacking a clinically useable non-invasive technique to measure the abnormality of liver function. The purpose of this study is to investigate the potential correlation between Fat Fraction (FF), R2* and liver function indexes in patients with cirrhosis using mDIXON-Quant sequence. We found that there was a moderate correlation between R2* value and liver function assay indexes in liver cirrhosis.

Tianzhu Liu¹, Weiyin Vivian Liu², Jun Chen¹, Lesheng Huang¹, Hongyi Li¹, Jinghua Jiang¹, Kaili Cai¹, Jiahui Tang¹, Wanchun Zhang¹, Kailian Yang¹, Guangjun Tian³, Meng Hu³, Se Peng⁴, Dong Zhang³, Dong Zhang³, Dan Li³, and Yongxiang Zhuo^3
1Radiology, Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, Zhuhai, China, ²MR Research, GE Healthcare, Beijing, China, Beijing, China, ³Hepatology, Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, Zhuhai, China, ⁴Laboratory, Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, Zhuhai, China

This study aimed to investigate the repeatability and reliability of IVIM derived parameters in evaluation of liver heterogeneity. Patients with early liver fibrosis and healthy subjects were recruited and underwent MRI using respiratory triggered SS-DWI with 12 b values and an IDEAL-IQ sequence. Two readers independently analyzed liver segment data using mono-exponential, bi-exponential and stretched exponential models. CVs and ICCs were calculated before and after the exclusion of subjects with potential liver fat deposition. ADC, D and α measurements of right liver lobe were satisfactorily repeatable, regardless of fat deposition. Segment-VII and -VIII values may be more repeatable and reliable.

Aina HUANG¹, Jian LU¹, Tao ZHANG¹, Xueqin ZHANG¹, Shuangshuang LU², and Xiance ZHAO^3
1Affiliated Nantong Hospital 3 of Nantong University, Nantong, Jiangsu, China, ²Affiliated Hospital of Nantong University, Nantong，Jiangsu, China, ³Philips Healthcare, Shanghai, China

Synopsis: The purpose of this study was to explore the evaluation value of liver fibrosis staging and hepatitis activity of chronic hepatitis B based on multi-sequence MRI radiomics model. Unenhanced T2WI, T1WI and Gd-EOB-DTPA enhanced T1WI, including AP, PP, TP and HBP, were acquired. And a multi-sequence MRI radiomics model were built. We used receiver operating characteristic (ROC) curves for the diagnostic performance of each sequence and the combination of these six sequences in the training set and validated with the validation set. The models combined with six sequences performed the best. 

Yue Wang¹, Ye Ju¹, Liangjie Lin², and Ailian Liu^1
1the First Affiliated Hospital of Dalian Medical University, Dalian, China, ²Philips Healthcare, Beijing, China

Chronic kidney disease (CKD), which has shown increased incidence  gradually, is prevalent worldwide and occurs in conjunction with cardiovascular disease and diabetes. Purpose of this study is to evaluate the value of quantitative T1 and R2* mapping in diagnosis of CKD. Results showed that renal cortex R2* and T1 values can be used to distinguish mild CKD from healthy volunteers, and the combination of them can improve the diagnostic efficiency. Cortex R2*, cortex T1, and medulla T1 values can be used to distinguish mild from severe CKD, and the diagnostic efficiency was also significantly improved by using their combination.

Xiaodong Liu¹, Lihua Chen¹, Wen Shen¹, Kun Zhang¹, Xiaodong Ji¹, Robert Grimm², and Jinxia Zhu^3
1Department of Radiology, Tianjin First Central Hospital, Tianjin, China, ²MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany, ³MR Collaboration, Siemens Healthcare Ltd., Beijing, China

This study investigated the feasibility of predicting early renal function impairment after renal transplantation based on an intravoxel incoherent motion imaging (IVIM)diffusion weighted imaging (DWI)radiomics model. For noninvasive detection of kidney function impairment at an early stage, IVIM-DWI applies a bi-exponential model to evaluate both capillary perfusion and tissue diffusion. The overall accuracy of the radiomics model was 79.3%, with 73.3% sensitivity and 85.7% specificity in distinguishing renal function impairment after renal transplantation. These results demonstrate the potential of a radiomics model for a reliable non-invasive diagnosis of renal transplant function.

Huan Zhao¹, Yan Bai¹, Xianchang Zhang², and Meiyun Wang^1
1Henan Provincial People's Hospital, Zhengzhou, China, ²MR Collaboration,Siemens Healthineers Ltd., Beijing, China

Conventional MRI is limited in reflecting tumor genetic status. This study used the parameters derived from histogram analysis of apparent diffusion coefficient(ADC) maps in glioma lesion to predict the MGMT and P53 gene status. We found the ADC histogram derived parameters are significantly higher in MGHT-methylated and P53 wild group. ROC analysis revealed these parameters have high sensitivity to differentiate the MGHT-methylated/-unmethylated or P53 wild/ mutant gliomas. These findings suggest ADC histogram could be a good candidate for predicting MGMT promoter methylation and P53 gene status in gliomas.

Sachi Okuchi¹, Yasutaka Fushimi¹, Satoshi Nakajima¹, Akihiko Sakata¹, Takuya Hinoda¹, Sayo Otani¹, Azusa Sakurama¹, Krishna Pandu Wicaksono¹, Hiroshi Tagawa¹, Yang Wang¹, Satoshi Ikeda¹, Kun Zhou², and Yuji Nakamoto^1
1Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ²Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China

TGSE-BLADE DWI has been reported to reduce geometric distortion and susceptibility artifacts. However, it is unknown whether it reduces the clip-induced artifacts and improves image quality in patients after cerebral aneurysmal clipping. We compared the distortion and the artifacts between SS-EPI, RESOLVE, and TGSE-BLADE DWI in healthy volunteers and patients with a cerebral aneurysmal clip. TGSE-BLADE DWI has the best image quality regarding distortion and artifacts, especially at air-bone interfaces and near metal clips, which suggests that TGSE-BLADE DWI is a promising method for evaluating lesions at air-bone interfaces and scanning the patients with a clip.