Juan Liang¹, Yurong Ma¹, Na Han¹, Kai Ai², and Jing Zhang^1
1Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China, ²Philips Healthcare, Xi'an, China

This study mainly uses the non-contrast whole-heart magnetic resonance coronary angiography (NCE-CMRA) to evaluate coronary artery lesion (CAL) in children with Kawasaki disease (KD), and analyze the mechanism of inflammatory factors in the occurrence and development of coronary artery lesions in KD. Multiple linear regression was used to analyze the correlation between inflammatory factors and the severity of CAL. Platelet, PCT, ESR, CRP, D-dimer, albumin, and leukocyte have certain diagnostic value for KD, among which ESR is the most sensitive. Therefore, NCE-CMRA combined with inflammatory indicators is helpful for early diagnosis and prognostic evaluation of CAL in children with KD.

Yu-Ru Yang¹, Meng-Chu Chang¹, Ming-Ting Wu², Ken-Pen Weng³, and Hsu-Hsia Peng^1
1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, ²Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ³Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

In this study, we defined a ratio of aortic KE and LV KE to represent LV-Ao efficiency. We aimed to evaluate LV-Ao energy efficiency in rTOF patients and evaluate the relationship between LV-Ao efficiency and RV hypertrophy. The aortic root KE, LV KE, and LV-Ao efficiency in rTOF group were comparable with normal group. The indexed LV-Ao efficiency was negatively correlated with age and RV volumetric parameters. The association between LV-Ao efficiency and age and RV hypertrophy suggested that the adverse interaction between RV and LV was expanded to the aorta in rTOF patients with preserved LV function. 

Zhenfeng Lv¹, Lianming Wu², Jilei Zhang³, Weibo Chen³, and Haikun Qi^1
1School of Biomedical Engineering, ShanghaiTech University, Shanghai, China, ²Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, ³Philips Healthcare, Shanghai 200040, P. R. China, Shanghai, China

Diffusion-weighted imaging (DWI), being able to detect the diffusion of water molecules in the tissue, is one of the potential techniques for the diagnosis of myocardial infarction without contrast agent administration. In this study, we investigated the diagnostic value of the mono-exponential and stretched exponential DWI model in the assessment of acute myocardial infarction. The preliminary results from 10 patients showed that the diffusion parameters were significantly lower in the infarcted region, and both models had capability of diagnosing acute myocardial infarction with the stretched exponential model performing slightly better.

Jianing Cui¹, Tao Li¹, Yanan Zhao¹, and Xiuzheng Yue^2
1Department of Radiology, the First Medical center, Chinese People's Liberation Army Hospital, Beijing, China., Beijing, China, ²Philips Healthcare, Beijing, China, Beijing, China

Over the past few decades, all-cause mortality and cardiovascular events have remained high in ST-segment elevation myocardial infarction (STEMI) patients. One of the reasons for this is that adverse LV remodeling of the heart that occurs in many patients after myocardial infarction. Cardiac magnetic resonance (CMR) imaging has become a beneficial imaging modality to assess myocardial morphology, LV function and infarct characteristics simultaneously. This study analyzed the value of LV volumes, LV function and infarct characteristics by CMR predicting adverse LV remodeling after STEMI. Our data showed that total enhanced volume was the most accurate prediction parameter.

Hung-Wei Wei Wang¹, Ming-Ting Wu², Ken-Pen Weng^3,4, and Hsu-Hsia Peng^5
1National Tsing Hua University, Hsinchu, Taiwan, ²Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ³Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ⁴Department of Pediatrics, National Yang-Ming University, Taipei, Taiwan, ⁵Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan

Repaired tetralogy of Fallot (rTOF) caused diffuse fibrosis due to adverse  ventricular reconstruction. T1 mapping was employed to observe the diffuse fibrosis. In patients, the native T1 and peak diastolic longitudinal velocity (Vz) were found to be different from the normal group. We aimed to investigate the relationship between left ventricular myocardial motion and myocardial fibrosis in patients with rTOF.

Yuze Li¹, Chunyan Wu¹, Haikun Qi², Dongyue Si¹, Haiyan Ding¹, and Huijun Chen^1
1Center for Biomedical Imaging Research, School of Medicine, Tsinghua University, Beijing, China, ²School of Biomedical Engineering, ShanghaiTech University, Shanghai, China

A motion correction method for myocardial T1 mapping using Self-supervised Deep learning based Registration with contrAst seParation (SDRAP) was proposed. A sparse coding based method was firstly proposed to separate the contrast component from T1w images. Then, a self-supervised deep neural network was developed to register contrast separated images, followed by the signal fitting to generate motion corrected T1 maps. Models were trained and tested in 47 healthy volunteers using MOLLI sequence, and compared with Free Form Deformation method. Results showed the proposed method can achieve better performance in registration and T1 mapping with higher efficiency (7x acceleration).

Jianing Cui¹, Tao Li¹, Yanan Zhao¹, Wei Wang¹, Wenjia Liu¹, Yundai Chen², Geng Qian², Xiuzheng Yue³, and Yishi Wang^3
1Department of Radiology, the First Medical center, Chinese People's Liberation Army Hospital, Beijing, China., Beijing, China, ²Department of Cardiology, The Six Medical Center, Chinese People's Liberation Army Hospital , Beijing, China., Beijing, China, ³Philips Healthcare, Beijing, China, Beijing, China

Effective risk assessment and stratification are essential for the clinical management of ST-segment elevation myocardial infarction (STEMI) patients. CMR imaging has become a beneficial imaging modality to assess myocardial morphology, function and infarct characteristics simultaneously. This study quantitatively evaluated the relationship between infarct size, regional myocardial function by cardiac magnetic resonance feature tracking strain analysis and infarct location in patients with STEMI treated by primary percutaneous coronary intervention. Our data showed that myocardial damage was more extensive and regional myocardial function in infarct zone was lower in the anterior wall myocardial infarction group compared to non-anterior wall myocardial infarction group.

Qiming Liu¹, Yezi Chai¹, Meng Jiang¹, and Chenxi Hu^2
1Department of Cardiology, Ren Ji Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²Institute of Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, shanghai, China

Differentiating hypertrophic cardiomyopathy (HCM) from hypertensive heart disease (HHD) is important yet challenging. In this study, we compared 9 convolutional neural network (CNN) models based on cardiac MR cine imaging only for differentiation of the two diseases. We show that the dynamic information contained in cine about myocardial contraction and relaxation is crucial for accurate differentiation. By leveraging this information, we achieved a testing accuracy of 86.8% ± 3.5% in a cohort including 190 HCM and 113 HHD subjects. The results show that cine-based CNN is reasonably accurate for differentiation of HCM and HHD.

Xianghu Yan¹, Lu Huang¹, Lingping Ran¹, Yi Luo¹, Yuwei Bao¹, Shuheng Zhang², Shiyu Zhang², Yongquan Ye³, Jian Xu³, and Liming Xia^1
1Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ²United Imaging Healthcare, Shanghai, China, ³UIH America, Inc., Houston, TX, United States

Cardiovascular magnetic resonance (CMR) T2-weighted dark blood (T2W-DB) imaging has great diagnostic value for detecting myocardial edema. In this study, a novel deep learning based acceleration framework (AI-assisted Compressed Sensing, ACS) was applied to a single-shot T2W-DB sequence for single breath-hold whole heart (9 slices) imaging. Both quantitative and qualitative assessment of the images suggested that the ACS T2-DB sequence offered better image quality with greatly reduced total scan time and the simplified scanning workflow.

Zhongsen Li¹, Hanyu Wei¹, Shuo Chen¹, Chuyu Liu¹, Mingzhu Fu¹, Wei Qiu¹, Shuai Wang¹, Haining Wei¹, Haozhong Sun¹, Xihai Zhao¹, and Rui Li^1
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China

In this study we have realized a real-time free-running cardiac imaging technique which can provide a continuous high-temporal-resolution movie of the heart during the whole acquisition process. This technique is based on the constrained partial separable model, which has been elaborately designed and optimized to achieve maximum reconstruction speed. Over two thousands dynamic frames of the heart can be acquired and reconstructed in just only 1 minute, without any ECG or respiratory monitoring devices needed. This technique has great potential for the cardiac imaging for patients with arrhythmia.

Jianhui Li¹, Yanzhen Liu¹, Yanhe Ma¹, Anhong Yu¹, Yapeng Yang¹, Jiwei Sun¹, Jianxiu Lian², and Hong Zhang^1
1Department of Radiology, Tianjin Chest Hospital, Tianjin, China, ²Philips Healthcare, Beijing, China

Atrial fibrillation increases mortality and is an independent risk factor for heart failure and stroke. Cardiac magnetic resonance feature tracking (CMR-FT) is a post-processing technique that can quantitatively assess myocardial deformation. The result showed that patients with Atrial fibrillation had lower left ventricle longitudinal strain (LVLS) and left atrial longitudinal strain（LALS）compared with healthy control，which may due to impaired function and myocardial injury. Therefore, measuring the longitudinal strain of the left atrium and left ventricle can be used as an important method to evaluate the function of patients with atrial fibrillation.

Keyan Wang¹, Wenbo Zhang¹, Shuman Li¹, Hongrui Jin¹, Yanan Jin¹, Yanan Jin¹, Li Wang², Ran Li³, Yang Yang⁴, Jingliang Cheng¹, Jie Zheng⁵, and Jing An^6
1MRI department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ²Pathology department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ³Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, United States, ⁴Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁵Washington University School of Medicine, Saint Louis, MO, United States, ⁶Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China

This study evaluated a cardiac T1ρdispersion mapping technique, termed as myocardial fibrosis index (mFI), to distinguish various levels of fibrosis in different subtypes of hypertrophic cardiomyopathy (HCM). These subtypes included patients with or without obstructive HCM, and with or without hypertrophic myocardial segments. Our data demonstrated that the mFI is equal to or significantly better than other cardiac fibrosis index, contrast-derived extracellular volumes, and native T1 values.

zheng zhang^1,2, Xing Chen³, Zhiwen You³, Jianmin Yuan², Lingzhi hu⁴, Jun Zhao³, and Chenxi Hu^1
1Shanghai Jiao Tong University, Shanghai, China, ²United Imaging Healthcare Co. Ltd., Shanghai, China, ³Shanghai East Hospital, Shanghai, China, ⁴United Imaging Healthcare Co. Ltd., Houston, TX, United States

A two-stage cardiac PET/late gadolinium enhancement (LGE) co-registration method proposed here significantly improved the co-registration between PET and LGE in integrated PET/MR imaging. The two-stage method led to increased registration score (4.93±0.89) versus no-registration (3.49±0.84, p<0.001) and a single-stage method (4.23±0.81, p<0.001), an increased SUV value in the normal myocardium (3.87±2.56) compared with the no-registration (3.14±1.92, p<0.001) and the single-stage method (3.32±2.16, p<0.001). The technique may improve diagnostic accuracy of non-ischemic cardiomyopathies via better image co-registration.

li jinshui¹ and he yi^1
1Beijing Friendship Hospital, bei jing, China

By comparing the three kinds of LGE images of 110 patients with AMI, and taking the current standard turbo FLASH imaging sequence as reference, this study verified the accuracy of using moco bSSFP and TrueFISP to evaluate the lesions in patients with AMI. The research covers image quality evaluation and qualitative diagnosis accuracy evaluation. The results show that moco bSSFP sequence and TrueFISP sequence have equivalent effect as turbo FLASH sequence in the qualitative diagnosis, but their image quality is better than that of turbo FLASH sequence.