Fengdan Wang¹, Francesco Santini², Jinxia Zhu³, Tom Hilbert^4,5,6, Tobias Kober^4,5,6, and Zhengyu Jin^1
1Radiology, Peking Union Medical College Hospital, Beijing, China, ²University Hospital Basel, Basel, Switzerland, ³Siemens Healthcare Ltd., Beijing, China, ⁴Siemens Healthcare AG, Lausanne, Switzerland, ⁵Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ⁶École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

Idiopathic Inflammatory Myopathy (IIM) is a group of immune-mediated myopathies, with high morbidity and mortality. Prior work showed that dedicated accelerated T2 mapping of bilateral thighs can be performed within 3 minutes at high resolution and can detect IIM-induced muscle inflammation. However, manual drawing methods to delineate regions of interest are subject to sampling errors. This study investigated the first utility of a fully automated deep-learning method for segmentation of T2 maps in 64 patients with IIM against healthy controls, with results confirming its feasibility, accuracy, and efficiency.
 

Liping Ma¹, Long Qian², Zhibin Zeng¹, Cuiyun Sheng¹, Yang Wang¹, Gen Li³, and Gaoyun Wu^1
1Department of Radiology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, China, ²MR Research, GE Healthcare, Bejing, China, ³Department of Emergency, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, China

Quantification of fat fraction (FF) and R2* in areas of bone marrow edema (BME) and fat metaplasia in different stages Ankylosing Spondylitis (AS). 75 AS in 3 different stage (early acute group, late acute group, stable group), 42 BME and 39 fat metaplasia were detected. Difference of FF, R2* in BME and fat metaplasia in different stages were compared and relationship between FF and R2* were analyzed. Result showed R2* in fat metaplasia, but not in BME, is significantly negative with FF. FF and R2* measurements can quantitatively analyze bone marrow component change in AS.

Xinxin Zhao¹, Jingjing Ruan¹, Jia Li², Chengxiang Dai³, and Yan Zhou^1
1Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160, Pujian Road, Shanghai, 200127, China., Shanghai, China, ²Department of Rheumatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160, Pujian Road, Shanghai, 200127, China., Shanghai, China, ³Cellular Biomedicine Group, Inc., No. 85 Faladi Road, Building 3, Zhangjiang, Pudong New Area, Shanghai, 201210, China., Shanghai, China

We used 3D texture analysis of MRI relaxation times, combined with clinical outcomes, to evaluate the potential of repair cartilage with allogeneic human adipose-derived mesenchymal progenitor cells in patients with KOA. Significant differences were observed in texture RLM parameters of T1rho and T2 maps in patients. We also found correlations between WOMAC pain scores and texture parameters, suggesting the spatial heterogeneity of relaxation time maps maybe associated with clinical scores. As conclusion, texture analysis has potential applications in understanding mechanism of stem cells repairing cartilage and assessing response to treatment.

Ming Wen¹, Yujin Zhang¹, Jianling Cui¹, and Zhiwei Shen^2
1The Third Hospital, Hebei Medical University, Shijiazhuang, China, ²Philips healthcare，Beijing，China, Beijing, China

Amide proton transfer (APT) imaging is a noninvasive emerging molecular MRI technique. Currently, APT was mainly used for the diagnosis, classify and recurrence prediction of head glioma. The application in other tissue such as musculoskeletal disease is limited. The feasibility and the repeatability of APT imaging in body or other tissues is necessary for its clinical practice. In this study, we explorer the scan-rescan repeatability of APT imaging in musculoskeletal (MSK) tumor on a clinical 3.0T MR scanner, and further to differentiate malignant from benign solid tumors in the study.

Qingqing Zhu¹ and Mengxiao Liu^2
1department of radiology, Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, China, ²MR scientific Marketing, Diagnostic Imaging, Siemens Healthineers Ltd, Shanghai, China

The purpose of this study was to evaluate the relationship between magnetic resonance dynamic contrast-enhanced imaging and quantitative parameters of the ZOOMit-DWI technique and the activity of sacroiliac arthritis. Dynamic enhanced MRI microvascular permeability parameters can visually reflect the microcirculatory perfusion status of the subchondral bone marrow region of the sacroiliac joint, and its diagnostic efficacy is better than DWI-ADC. Sacral Ktrans values and sacral iAUC values are highly correlated with ASDAS-CRP scores, which can be used as important quantitative indicators for assessing the inflammatory activity of the sacroiliac joint.

Yuan Li¹, Guanhua Yang¹, Wei Jing¹, Shimin Lan¹, and Xiuzheng Yue^2
1The First People's Hospital of Shizuishan, Shizuishan, China, ²Philips Healthcare, Beijing, China

The aim of this study was to investigate the feasibility of T2* mapping, R2* mapping and T1 mapping techniques for quantitative assessment of primary osteoporosis of the lumbar spine.The differences and correlation between T2* mapping, R2* mapping and T1 mapping values of patients with osteoporosis group and the normal population were analyzed. The statistical results of our data showed that the T2 values in the osteoporotic group of L3 and L5 vertebrae were greater than the normal group, and the R2* values and T1 values were less than the normal group.

Lin Gengyun¹, Wu Junying¹, Wen Zhibo¹, and Zhao Chen^2
1Zhujiang Hospital, Guangzhou, China, ²Philips Healthcare, Guangzhou, China

Obesity is a global health condition that leads to many kinds of diseases. Bone marrow fat (BMF) is considered as the third largest fat depot in human body. It has been proved that BMF is closely related with energy storage, bone metabolism,  endocrine function and hematologic diseases. To understand the relation between BMF and weight loss is crucial within obesity related diseases scenario. Few studies have been published focusing on BMF variation so far. In this study, chemical shift encoding-based water-fat MRI (CSE-MRI) was employed to demonstrate the positive correlation between BMF and parts of the weight loss indicators.

Cui Ren¹, Qing Li², Stefan Sommer^3,4,5, Qiao Zhu¹, and Hui Shu Yuan^1
1Radiology, Peking University Third Hospital, Beijing, China, ²MR Collaborations, Siemens Healthineers Ltd., Shanghai, China, ³Siemens Healthcare, Zurich, Switzerland, ⁴Swiss Center for Musculoskeletal Imaging (SCMI), Balgrist Campus, Zurich, Switzerland, ⁵Advanced Clinical Imaging Technology (ACIT), Siemens Healthcare AG, Lausanne, Switzerland

To assess the diagnostic performance of three-dimensional ultrashort echo time sequence (3D-UTE) in bone erosion detection of the sacroiliac joint (SIJ) in patients with clinically confirmed ankylosing spondylitis (AS) and to test whether SIJ cartilage T2* values might help in identification of patients with AS.

Yang LI¹ and Nan Hong^1
1Peking university people's hospital, Beijing, China

Multiple myeloma (MM) is the second most common hematologic malignancy. Despite the more effective therapies were introduced, this incurable disease remains highly heterogeneous in clinical outcome. Accurate predicative markers for prognosis are needed to develop appropriate treatment in newly diagnosed MM.

Yang LI¹ and Nan Hong^1
1Peking university people's hospital, Beijing, China

The prognostic biomarkers for multiple myeloma (MM) was urgently needed, and this study was the first to confirm the value of Intravoxel Incoherent Motion-Diffusion Weighted Imaging (IVIM-DWI) for predicting progression-free survival in patients with MM.Purpose: To evaluate the prognostic ability of Intravoxel Incoherent Motion-Diffusion Weighted Imaging (IVIM-DWI) derived parameters in newly diagnosed multiple myeloma (MM).

Qiaoling Zhong¹, Xintao Zhang¹, Zhongping Zhang², and Xiaodong Zhang^1
1Department of Medical Imaging, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China, ²Philips Healthcare, Guangzhou, China

The knee joint is one of the most commonly affected large joint in rheumatoid arthritis (RA). Its progression often causes joint destruction and deformity. The cartilage injury, bone marrow lesions and synovitis scores of the knees at baseline, P-1 (1 year prior to P0), and P0 (time of onset of RA) were evaluated using the MOAKS score. The generalized estimation equation (GEE) was used to compare the MR scores of knee joints at three time points to observe the longitudinal changes. The changes of bone marrow lesions and synovitis scores in knee joints were significant before the occurrence of RA.

Wenzhao Yuan¹, Yi Dai², Yiwu Lei³, Fang Qin⁴, Huiting Zhang⁵, Zisan Zeng³, and Liling Long^1
1The First Affiliated Hospital of Guangxi Medical University, Nanning, China, ²Radiology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China, ³Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China, ⁴Rheumatology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China, ⁵Siemens Healthcare Ltd., Wuhan, China

This study evaluated the efficacy of MRI bone marrow edema imaging for rheumatoid arthritis (RA). Wrist joints of RA patients were examined at baseline and follow-up with T1 mapping, T2 mapping and IVIM, and their clinical indicator DAS28-ESR was also collected. Results showed that the changes of both T1 and D values had statistically positive correlations with DAS28-ESR. And the results showed that T1 and D values of bone marrow edema area in lunate bone, triangle bone and capitate bone can significantly reflect the curative effect of RA, and the change rate of T1 can predict the curative effect.