Bridging the Scales of Tissue Microstructure with Ultra-High Field MRI & Multi-Modal Imaging
Member-Initiated Symposium
Thursday, 12 May 2022
ICC Capital Suite 7 & 12
17:00 - 19:00
Session Number: MIS-06
Rebecca Glarin, Marta Bianciardi, and Benedikt Poser.
Overview
Characterization of tissue microstructure is key to understanding pathophysiological processes. The high SNR, spatial resolution and unique image contrast of ultra-high field (UHF) MRI enable non-invasive investigations of tissue microstructure, thereby bridging the gap between imaging and histology. Such detailed studies demand advancements in acquisition, reconstruction and analysis methods, as well as improvements of RF coils and parallel transmission.
This MIS focuses on how UHF MRI can expand the knowledge of microstructure in a range of organs, and on how these insights can be used in clinical research to ultimately impact patient care. A number of methods used to understand microstructural properties will be presented, including advanced quantitative susceptibility, diffusion and relaxivity parameter mapping. The talks will cover MRI studies of brain, bone and heart microstructure, including in-vivo applications with potential clinical impact, and validation with other modalities, such as optical imaging, X-Ray microtomography and histology that are more difficult to apply in vivo in humans.
The topic of the MIS is well aligned with the core mission of the High Field Systems and Applications study group: to advance UHF applications and the technological solutions that enable them. The methods and applications covered in this MIS, however, will be of interest to a broader audience of ISMRM members, connecting basic scientists and clinical researchers.
Target Audience
Researchers and clinicians interested in UHF method development and applications for the investigation of tissue properties in health and disease.
Educational Objectives
As a result of attending this course, participants should be able to:
Describe various techniques (e.g. quantitative susceptibility mapping, relaxometry, diffusion imaging) used to image tissue microstructure in preclinical and clinical studies and how they benefit from UHF|Understand how UHF complements the information from other modalities such as X-Ray microtomography, optical imaging and histology|Describe applications of UHF microstructure imaging in the study of brain, cardiac and musculoskeletal tissues|Describe the potential impact of UHF microstructure imaging in the clinic
17:00
Magnetic Susceptibility Imaging of Brain Microstructure Using Chi-Separation
Video Unavailable
Hyeong-Geol Shin
Seoul National University, Korea, Republic of
17:30
Probing Tissue Microstructure with Diffusion MRI & Tissue Clearing 3D Histology
Video Unavailable
Jennifer McNab
Stanford University, United States
18:00
Assessment of Bone Microstructure Using MRI & High-Resolution X-Ray Microtomography
Video Unavailable
David Bendahan
Aix Marseille University
18:30
Relaxivity & Diffusion Imaging of Cardiac Microstructure
The International Society for Magnetic Resonance in Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
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